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GAP43 Rabbit Polyclonal Antibody

CAT: 0992-ER40201Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER40201Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.
CAS Number
9007-83-4
Product Name Alternative
Axonal membrane protein GAP 43 antibody Axonal membrane protein GAP-43 antibody B 50 antibody Calmodulin binding protein P 57 antibody F1 antibody GAP 43 antibody GAP43 antibody Growth Associated Protein 43 antibody Growth-associated protein 43 antibody Nerve Growth Related Peptide antibody Nerve growth related peptide GAP43 antibody NEUM_HUMAN antibody Neural phosphoprotein B 50 antibody Neural phosphoprotein B-50 antibody Neuromodulin antibody Neuron growth associated protein 43 antibody PP46 antibody Protein F1 antibody QtrA-11580 antibody QtrA-13071 antibody
Abbreviation
NEUM,Gap43
Swiss Prot
P17677 Human, P06837 Mouse, P07936 Rat
Cellular Locus
Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within mouse GAP43 aa 178-227 / 227.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SH-SY5Y cell lysate, Neuro-2a cell lysate, mouse brain tissue lysate, rat brain tissue lysate, Neuro-2a, rat brain tissue, mouse brain tissue, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB: 1:100,000 ;IF-Cell: 1:200 ;IHC-P: 1:1,000 ;FC: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 25 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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TA357837GAP43 Rabbit Polyclonal Antibody

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