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ROCK1 Rabbit Polyclonal Antibody

CAT: 0992-ER40122Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER40122Size:100 µL
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Description
ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has a diverse range of functions in the body. It is a key regulator of actin-myosin contraction, stability, and cell polarity. These contribute to many progresses such as regulation of morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.
CAS Number
9007-83-4
Product Name Alternative
coiled-coil-containing protein kinase 1 antibody coiled-coil-containing protein kinase I antibody MGC131603 antibody MGC43611 antibody p160 Rhoassociated coiled coil-forming protein kinase antibody p160 ROCK-1 antibody p160 ROCK1 antibody p160ROCK antibody PRO0435 antibody Renal carcinoma antigen NY REN 35 antibody Renal carcinoma antigen NY-REN-35 antibody Rho associated coiled coil containing protein kinase 1 antibody Rho associated protein kinase 1 antibody Rho kinase antibody Rho-alpha kinase antibody Rho-associated antibody Rho-associated protein kinase 1 antibody ROCK I antibody ROCK-I antibody ROCK1 antibody ROCK1_HUMAN antibody Rok antibody rokalpha antibody
Abbreviation
ROCK-I,p160ROCK
Swiss Prot
Q13464 Human, P70335 Mouse, Q63644 Rat
Cellular Locus
Cytoplasm, cell membrane, Nucleus, Cell projection, Cytoskeleton, Golgi apparatus, Membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within residues of ROCK1 aa 1,305-1,354 / 1,354.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
A431 cell lysate, human lung tissue lysate, mouse spleen tissue lysate, C6 cell lysate, L6 cell lysate, human colon cancer tissue, HepG2.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IHC-P: 1:200 ;IF-Cell: 1:50 ;FC: 1:100-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 158 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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