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Desmin Rabbit Polyclonal Antibody

CAT: 0992-ER40113Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER40113Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. Desmin is also important in muscle cell architecture and structure since it connects many components of the cytoplasm. Finally, desmin may be important in mitochondria function. Desmin-related myopathy (DRM or Desminopathy) is a subgroup of the myofibrillar myopathy diseases and is the result of a mutation in the gene that codes for desmin which prevents it from forming protein filaments, instead forming aggregates of desmin and other proteins throughout the cell. Recently, mutations were identified in patients suffered by an arrhythmogenic right ventricular cardiomyopathy (ARVC).
CAS Number
9007-83-4
Product Name Alternative
CMD1I antibody CSM1 antibody CSM2 antibody DES antibody DESM_HUMAN antibody Desmin antibody FLJ12025 antibody FLJ39719 antibody FLJ41013 antibody FLJ41793 antibody Intermediate filament protein antibody OTTHUMP00000064865 antibody
Swiss Prot
P17661 Human
Cellular Locus
Cytoplasm, Cell membrane, Intermediate filament, Membrane, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Zebrafish
Immunogen
Recombinant protein within human Desmin aa 405-470/470.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Human heart tissue lysate, human skeletal muscle tissue lysate, mouse heart tissue lysate, human uterus tissue, mouse skeletal muscle tissue, mouse heart tissue, hybrid fish (crucian-carp) brain tissue lysate, HepG2, NIH-3T3, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:200;IHC-P: 1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 54 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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