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PUMA Rabbit Polyclonal Antibody

CAT: 0992-ER31215Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER31215Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death. Several studies have shown that PUMA function is affected or absent in cancer cells. Additionally, many human tumors contain p53 mutations, which results in no induction of PUMA, even after DNA damage induced through irradiation or chemotherapy drugs.Other cancers, which exhibit overexpression of antiapotptic Bcl-2 family proteins, counteract and overpower PUMA-induced apoptosis.
CAS Number
9007-83-4
Product Name Alternative
BBC 3 antibody Bbc3 antibody BBC3_HUMAN antibody BCL 2 binding component 3 antibody Bcl-2-binding component 3 antibody BCL2 binding component 3 antibody JFY 1 antibody JFY-1 antibody JFY1 antibody p53 up regulated modulator of apoptosis antibody p53 up-regulated modulator of apoptosis antibody p53 Upregulated Modulator of Apoptosis antibody PUMA alpha antibody PUMA/JFY1 antibody
Abbreviation
PUMA,BBC3
Swiss Prot
Q9BXH1 Human
Cellular Locus
Mitochondrion.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within C-terminal residues of PUMA.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Hela cell lysate, Mouse kidney tissue lysate, SKOV-3, Hela, Lovo, human breast cancer tissue, mouse small intestine tissue, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:200 ;FC:1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 21 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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