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CBL Rabbit Polyclonal Antibody

CAT: 0992-ER2001-61Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-61Size:100 µL
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Description
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome . Ubiquitinates SPRED2 . Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).
CAS Number
9007-83-4
Product Name Alternative
4732447J05Rik antibody C CBL antibody Cas Br M (murine) ecotropic retroviral transforming sequence antibody Casitas B lineage lymphoma proto oncogene antibody Casitas B-lineage lymphoma proto-oncogene antibody CBL 2 antibody cbl antibody CBL_HUMAN antibody CBL2 antibody E3 ubiquitin protein ligase CBL antibody E3 ubiquitin-protein ligase CBL antibody Oncogene CBL2 antibody Proto oncogene c CBL antibody Proto-oncogene c-CBL antibody RGD1561386 antibody RING finger protein 55 antibody RNF55 antibody Signal transduction protein CBL antibody
Abbreviation
E3 ubiquitin-protein ligase CBL Casitas B-lineage lymphoma proto-oncogene Proto-oncogene c-Cbl RING finger protein 55 RING-type E3 ubiquitin transferase CBLC Signal transduction protein CBL
Swiss Prot
P22681 Human
Cellular Locus
Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human C-CBL aa 580-630.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
293T cell lysates.
Concentration
1 mg/mL
Dilution
WB: 1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 100 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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