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GADD34 Rabbit Polyclonal Antibody

CAT: 0992-ER2001-56Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-56Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene. The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation of eIF2α and reversing translational inhibition. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
CAS Number
9007-83-4
Product Name Alternative
Apoptosis associated protein antibody GADD 34 antibody Growth arrest and DNA damage inducible 34 antibody Growth arrest and DNA damage-inducible protein GADD34 antibody Myeloid differentiation primary response protein MyD116 homolog antibody Ppp1r15a antibody PR15A_HUMAN antibody Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody Protein phosphatase 1 regulatory subunit 15A antibody
Abbreviation
Protein phosphatase 1 regulatory subunit 15A Growth arrest and DNA damage-inducible protein GADD34 Myeloid differentiation primary response protein MyD116 homolog
Swiss Prot
O75807 Human
Cellular Locus
Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human GADD34 aa 1-50.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
HepG2 cell lysate, A431 cell lysate, human skin tissue, human prostate carcinoma tissue, human placenta tissue, K562.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IHC-P: 1:50-1:1200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 73 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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