AKR1B1 Rabbit Polyclonal Antibody

AKR1B1 Rabbit Polyclonal Antibody

• Description: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia . Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal . Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) .
• Product Name Alternative: ADR antibody AKR1B 1 antibody Akr1b1 antibody Aldehyde reductase 1 antibody Aldehyde reductase antibody Aldo keto reductase family 1, member B1 antibody Aldo-keto reductase family 1 member B1 antibody aldo-keto reductase family 1, member B1 (aldose reductase) antibody Aldose reductase antibody aldr 1 antibody ALDR_HUMAN antibody aldr1 antibody ALR2 antibody AR antibody Lii5 2 CTCL tumor antigen antibody Low Km aldose reductase antibody MGC1804 antibody
• Abbreviation: Aldo-keto reductase family 1 member B1 Aldehyde reductase Aldose reductase AR
• CAS Number: 9007-83-4
• Swiss Prot: P15121 Human
• Cellular Locus: Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthetic peptide within human AKR1B1 aa 1-50.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Rat skeletal muscle tissue lysate, A549 cell lysate, rat seminal vesicle tissue, human seminal vesicle tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:100-1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 36 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No