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KPTN Rabbit Polyclonal Antibody

CAT: 0992-ER2001-17Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-17Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Mutations in this gene result in an autosomal recessive form of intellectual disability. Alternatively spliced transcript variants have been found for this gene.
CAS Number
9007-83-4
Product Name Alternative
2E4 antibody actin associated protein 2E4 antibody actin binding protein antibody Actin-associated protein 2E4 antibody Kaptin antibody Kptn antibody KPTN protein antibody KPTN_HUMAN antibody
Abbreviation
KPTN
Swiss Prot
Q96GT1 Human, Q9Y664 Human, Q8VCX6 Mouse
Cellular Locus
Lysosome membrane, lamellipodium, stereocilium.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within N-terminal human KPTN.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
HepG2 cell lysate, SH-SY5Y cell lysate, rat brain tissue lysate, human placenta tissue, mouse testis tissue, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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