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Ki67 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-75Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-75Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
CAS Number
9007-83-4
Product Name Alternative
Antigen identified by monoclonal antibody Ki 67 antibody Antigen identified by monoclonal antibody Ki-67 antibody Antigen KI-67 antibody Antigen KI67 antibody Antigen Ki67 antibody KI67_HUMAN antibody KIA antibody Marker of proliferation Ki-67 antibody MIB 1 antibody MIB antibody MKI67 antibody PPP1R105 antibody Proliferation marker protein Ki-67 antibody Proliferation related Ki 67 antigen antibody Protein phosphatase 1 regulatory subunit 105 antibody RP11-380J17.2 antibody
Abbreviation
Proliferation marker protein Ki-6,Antigen identified by monoclonal antibody Ki-67,Antigen KI-67,Antigen Ki67,MKI67
Swiss Prot
P46013 Human
Cellular Locus
Chromosome, Nucleus
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Ki67 aa 1,949-1,998 / 3,256.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
HepG2 cell lysates, A549, human colon cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:10,000-1:50,000 ;IHC-P: 1:200-1:1,000 ;IF-Cell: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 359 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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