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FEN1 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-64Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-64Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
CAS Number
9007-83-4
Product Name Alternative
DNase IV antibody FEN-1 antibody FEN1 antibody FEN1_HUMAN antibody Flap endonuclease 1 antibody Flap structure specific endonuclease 1 antibody Flap structure-specific endonuclease 1 antibody hFEN-1 antibody hFEN1 antibody Maturation factor 1 antibody MF1 antibody Rad2 antibody
Abbreviation
Flap endonuclease 1,FEN-1,DNase IV Flap structure-specific endonuclease 1UniRule annotation Maturation factor 1 MF1 hFEN-1 FEN1
Swiss Prot
P39748 Human, P39749 Mouse, Q5XIP6 Rat
Cellular Locus
Mitochondrion, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human FEN1 aa 170-380 / 380.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
WB: K562 cell lysate, Daudi cell lysate, SHSY5Y cell lysate. ICC: MCF-7 cell, SHSY5Y cell. IHC: Human tonsil tissue, human lung cancer tissue, human colon tissue, mouse testis tissue. FC: MG-63 cell.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IHC-P: 1:50-1:200;IF-Cell: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 42 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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