Products for Research Use Only
RegisterLogin

PTEN Rabbit Polyclonal Antibody

CAT: 0992-ER1902-33Size: 100 µLDry Ice: NoHazardous: No
Product image 1Product image 2Product image 3
1 / 3
CAT#:0992-ER1902-33Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
CAS Number
9007-83-4
Product Name Alternative
10q23del antibody BZS antibody DEC antibody GLM2 antibody MGC11227 antibody MHAM antibody MMAC1 antibody MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody Mutated in multiple advanced cancers 1 antibody Phosphatase and tensin homolog antibody Phosphatase and tensin like protein antibody Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN antibody Pten antibody PTEN_HUMAN antibody PTEN1 antibody TEP1 antibody
Abbreviation
PTEN
Swiss Prot
P60484 Human, O08586 Mouse, O54857 Rat
Cellular Locus
Cell projection, Cytoplasm, Nucleus, Secreted, Synapse.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within human PTEN aa 350-403.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
MCF-7 cell lysate, Hela cell lysate, 293T cell lysate, THP-1 cell lysate, rat cerebellum tissue, human cervix tissue, human breast carcinoma tissue, human kidney tissue, mouse brain tissue, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 47 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

Related Products

CatalogName
HA750105PTEN Recombinant Rabbit monoclonal Antibody
ET1606-43PTEN Recombinant Rabbit Monoclonal Antibody [SJ19-03]
HA721962PTEN Recombinant Rabbit Monoclonal Antibody [JE51-96]
ET1701-46Phospho-PTEN (S380) Recombinant Rabbit Monoclonal Antibody [JJ08-81]
ER1901-73GABARAPL2 Rabbit Polyclonal Antibody
ER2001-53Transferrin Rabbit Polyclonal Antibody
ER1802-12LSD1 Rabbit Polyclonal Antibody
HA500270AIM2 Rabbit Polyclonal Antibody
HA500595TMEM184A Rabbit polyclonal Antibody
HA500594HERC6 Rabbit polyclonal Antibody

Alternative Products

CatalogName
GTR18233019-01PTEN Rabbit Polyclonal Antibody
NB100-2229Rabbit Polyclonal PTEN Antibody

Popular Products