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ITCH Rabbit Polyclonal Antibody

CAT: 0992-ER1901-94Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-94Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Involved in the control of inflammatory signaling pathways . Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways . Promotes the association of the complex after TNF stimulation . Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains . This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response . Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages .
CAS Number
9007-83-4
Product Name Alternative
ADMFD antibody AIF4 antibody AIP4 antibody Atrophin 1 interacting protein 4 antibody Atrophin-1-interacting protein 4 antibody dJ468O1.1 antibody dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody E3 ubiquitin protein ligase Itchy homolog antibody E3 ubiquitin-protein ligase Itchy homolog antibody EC 6.3.2 antibody Itch antibody ITCH_HUMAN antibody Itchy E3 ubiquitin protein ligase antibody Itchy E3 ubiquitin protein ligase homolog antibody Itchy E3 ubiquitin protein ligase homolog mouse antibody Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody Itchy homolog E3 ubiquitin protein ligase antibody Itchy mouse homolog E3 ubiquitin protein ligase antibody NAPP1 antibody NFE2 associated polypeptide 1 antibody NFE2-associated polypeptide 1 antibody Ubiquitin protein ligase ITCH antibody
Abbreviation
E3 ubiquitin-protein ligase Itchy homolog ,Itch.Atrophin-1-interacting protein 4,AIP4,NAPP1,ITCH
Swiss Prot
Q96J02 Human, Q8C863 Mouse, A0A8I5ZZU1 Rat
Cellular Locus
Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human ITCH aa 302-481 / 903.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
Siha cell lysates, A431 cell lysates, Mouse spleen tissue lysates, Mouse pancreatic tissue lysates, Hela, LOVO, Siha, Human liver cancer tissue, rat brain tissue, mouse pancreas tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1000-1:5000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:100-1:500 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 102/98/86 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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