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BCL2L15 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-44Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-44Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G (L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G (L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.
CAS Number
9007-83-4
Product Name Alternative
AC124698.1 antibody B2L15_HUMAN antibody Bcl-2-like protein 15 antibody Bcl2-L-15 antibody BCL2-like 15 antibody Bcl2l15 antibody Bfk antibody C1orf178 antibody FLJ22588 antibody Gm566 antibody Pro apoptotic Bcl 2 protein antibody
Abbreviation
BCL2L15
Swiss Prot
Q5TBC7 Human, Q08ED0 Mouse
Cellular Locus
Cytosol, nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human BCL2L15 aa 1-163 / 163.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Rat cecum tissue lysates, human small intestine tissue lysates, A549, MCF-7, SKOV-3, rat large intestine tissue, mouse large intestine tissue, mouse colon tissue.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000;IF-Cell:1:50-1:100;IHC-P:1:50-1:200;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 18 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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