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BIN1 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-39Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-39Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.
CAS Number
9007-83-4
Product Name Alternative
AMPH 2 antibody AMPH2 antibody Amphiphysin 2 antibody Amphiphysin II antibody Amphiphysin like protein antibody amphiphysin-like antibody Amphiphysin-like protein antibody AMPHL antibody Bin1 antibody BIN1_HUMAN antibody Box Dependant MYC Interacting Protein 1 antibody Box-dependent myc-interacting protein 1 antibody Bridging integrator 1 antibody DKFZp547F068 antibody MGC10367 antibody MGC105358 antibody Myc box dependent interacting protein 1 antibody Myc box-dependent-interacting protein 1 antibody SH3P9 antibody
Abbreviation
BIN1, AMPHL
Swiss Prot
O00499 Human, O08539 Mouse, O08839 Rat
Cellular Locus
Cell membrane, Cytoplasm, Endosome, Nucleus, Plasma membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human BIN1 aa 56-257 / 593.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Rat spleen tissue lysate, SiHa, rat brain tissue, human colon cancer tissue, human spleen tissue, human kidney tissue, mouse skeletal muscle tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 65 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No