BIN1 Rabbit Polyclonal Antibody

• Description:

  Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.

• Product Name Alternative:

  AMPH 2 antibody AMPH2 antibody Amphiphysin 2 antibody Amphiphysin II antibody Amphiphysin like protein antibody amphiphysin-like antibody Amphiphysin-like protein antibody AMPHL antibody Bin1 antibody BIN1_HUMAN antibody Box Dependant MYC Interacting Protein 1 antibody Box-dependent myc-interacting protein 1 antibody Bridging integrator 1 antibody DKFZp547F068 antibody MGC10367 antibody MGC105358 antibody Myc box dependent interacting protein 1 antibody Myc box-dependent-interacting protein 1 antibody SH3P9 antibody

• Abbreviation:

  BIN1, AMPHL

• Swiss Prot:

  O00499 Human, O08539 Mouse, O08839 Rat

• Cellular Locus:

  Cell membrane, Cytoplasm, Endosome, Nucleus, Plasma membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human BIN1 aa 56-257 / 593.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P

• Positive Control:

  Rat spleen tissue lysate, SiHa, rat brain tissue, human colon cancer tissue, human spleen tissue, human kidney tissue, mouse skeletal muscle tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 65 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4