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AKT3 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-33Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-33Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
CAS Number
9007-83-4
Product Name Alternative
Akt3 antibody AKT3 kinase antibody AKT3_HUMAN antibody DKFZp434N0250 antibody MPPH antibody PKB gamma antibody PKBG antibody PRKBG antibody Protein kinase Akt-3 antibody Protein Kinase AKT3 antibody Protein kinase B gamma antibody RAC gamma antibody RAC gamma serine/threonine protein kinase antibody RAC-gamma serine/threonine-protein kinase antibody RAC-PK-gamma antibody RACPK Gamma antibody Serine threonine protein kinase Akt 3 antibody Serine threonine protein kinase Akt3 antibody STK 2 antibody STK-2 antibody STK2 antibody V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) antibody V akt murine thymoma viral oncogene homolog 3 antibody V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma antibody
Abbreviation
AKT3
Swiss Prot
Q9Y243 Human, Q9WUA6 Mouse, Q63484 Rat
Cellular Locus
Nucleus, Cytoplasm, Membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human AKT3 aa 211-383 / 479.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
MCF7 cell lysate, Jurkat cell lysate, C6 cell lysate, rat heart tissue lysate, A549, EA.hy926, human thyroid tissue, human kidney tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IF-Cell:1:50-1:100 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 56 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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