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CD43 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-28Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-28Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4+ T-cells and to a lesser extent by CD8+ T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival.
CAS Number
9007-83-4
Product Name Alternative
CD 43 antibody CD43 antibody CD43 antigen antibody Galactoglycoprotein antibody GALGP antibody GPL 115 antibody GPL115 antibody Human gene for sialophorin antibody Leucocyte sialoglycoprotein antibody LEUK_HUMAN antibody Leukocyte large sialoglycoprotein antibody Leukocyte sialoglycoprotein antibody Leukosialin antibody LSN antibody Ly-48 antibody sialophorin (gpL115, leukosialin, CD43) antibody Sialophorin antibody Spn antibody
Abbreviation
SPN
Swiss Prot
P16150 Human
Cellular Locus
Membrane, microvillus, uropodium, nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human CD43 aa 351-400 / 400.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Human thymus tissue lysates, human tonsil tissue, human spleen tissue, Jurkat, K562 cell lysates.
Concentration
1mg/mL
Dilution
WB:1:500-1:2,000 ;ICC/ IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 40 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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