CD43 Recombinant Rabbit Monoclonal Antibody [PD01-28]

• Description:

  Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4+ T-cells and to a lesser extent by CD8+ T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival. CD43 is a transmembrane protein involved in immune function and T-cell activation. Anti-CD43 reactivity is seen in T lymphocytes, monocytes, and granulocytes. No reactivity has been observed in normal or reactive B-cells. Reportedly, anti-CD43 reactivity is seen in the majority of T-cell lymphomas and some low grade B-cell lymphomas. Therefore, anti-CD43 is a useful immunohistochemical marker for the identification of T-cell lymphomas and some low grade B-cell lymphomas.

• Product Name Alternative:

  CD 43 antibody CD43 antibody CD43 antigen antibody Galactoglycoprotein antibody GALGP antibody GPL 115 antibody GPL115 antibody Human gene for sialophorin antibody Leucocyte sialoglycoprotein antibody LEUK_HUMAN antibody Leukocyte large sialoglycoprotein antibody Leukocyte sialoglycoprotein antibody Leukosialin antibody LSN antibody Ly-48 antibody sialophorin (gpL115, leukosialin, CD43) antibody Sialophorin antibody Spn antibody

• Abbreviation:

  SPN GPL115 Galactoglycoprotein (GALGP) Leukocyte sialoglycoprotein Sialophorin CD43

• Swiss Prot:

  P16150 Human

• Cellular Locus:

  Membrane, microvillus, uropodium, nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within Human CD43 aa 200-300 (internal sequence).

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  IHC-P

• Positive Control:

  Human B-cell lymphoma tissue, human tonsil tissue.

• Concentration:

  1 mg/mL

• Dilution:

  IHC-P: 1:5,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 40 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3