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TRPML3 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-21Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-21Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity. Mediates release of Ca2+ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca2+ for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).
CAS Number
9007-83-4
Product Name Alternative
MCOLN 3 antibody MCOLN3 antibody FLJ11006 antibody FLJ36629 antibody MCLN3_HUMAN antibody Mcoln3 antibody MGC71509 antibody Mucolipin 3 antibody Mucolipin-3 antibody TRP ML3 antibody TRPML3 antibody
Abbreviation
Mcoln3
Swiss Prot
Q8TDD5 Human, Q8R4F0 Mouse,
Cellular Locus
Early endosome membran, late endosome membrane, stereocilium membrane, autophagosome membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human TRPML3 aa 504-553 / 553.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
A549 cell lysate, HL-60 cell lysate, HEK-293 cell lysate, mouse brain tissue lysate, mouse kidney tissue lysate, rat brain tissue lysate, rat kidney tissue lysate, human liver carcinoma tissue, F9.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IF-Cell:1:50 ;IHC-P:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 64 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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