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SSRP1 Rabbit Polyclonal Antibody

CAT: 0992-ER1901-13Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1901-13Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
CAS Number
9007-83-4
Product Name Alternative
Chromatin-specific transcription elongation factor 80 kDa subunit antibody Cisplatin DNA SSRP antibody Facilitates chromatin remodeling 80 kDa subunit antibody Facilitates chromatin transcription complex 80 kDa subunit antibody Facilitates chromatin transcription complex subunit SSRP1 antibody FACT 80 kDa subunit antibody FACT complex subunit SSRP1 antibody FACT80 antibody FACTp80 antibody hSSRP1 antibody Recombination signal sequence recognition protein 1 antibody Recombination signal sequence recognition protein antibody SSRP 1 antibody SSRP1 antibody SSRP1_HUMAN antibody Structure specific recognition protein 1 antibody Structure-specific recognition protein 1 antibody T160 antibody
Abbreviation
FACT 80 kDa subunit, FACTp80, hSSRP1, SSRP1, FACT80
Swiss Prot
Q08945 Human, Q08943 Mouse, Q04931 Rat
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human SSRP1 aa 192-375 / 709.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Daudi cell lysate, Hela cell lysate, 293 cell lysate, Jurkat cell lysate, rat testis tissue lysate, mouse testis tissue lysate, rat testis tissue, human skin tissue, human breast cancer tissue, mouse colon tissue, SH-SY5Y.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 81 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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