CBARA1 Rabbit Polyclonal Antibody

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Alternatively spliced transcript variants encoding different isoforms have been described.

9007-83-4

Allergen Hom s 4 antibody ara CALC antibody atopy related autoantigen antibody atopy related autoantigen CALC antibody Atopy-related autoantigen CALC antibody CALC antibody calcium binding atopy related autoantigen 1 antibody Calcium uptake protein 1 antibody calcium uptake protein 1, mitochondrial antibody Calcium-binding atopy-related autoantigen 1 antibody CBARA1 antibody EFHA3 antibody FLJ12684 antibody MICU1 antibody MICU1_HUMAN antibody mitochondrial antibody mitochondrial calcium uptake 1 antibody MPXPS antibody

ara CALC, MICU1, CALC, CBARA1

Q9BPX6 Human, Q8VCX5 Mouse, Q6P6Q9 Rat

Mitochondrion.

Recombinant protein within Human CBARA1 aa 14-154 / 476.

Non-conjugated

Rabbit polyclonal Antibody

WB

Mouse kidney tissue, rat brain tissue, Hela.

1 mg/mL

WB:1:500-1:2,000

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 54 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.