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CD13 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-74Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-74Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.
CAS Number
9007-83-4
Product Name Alternative
Alanyl (membrane) aminopeptidase antibody Alanyl aminopeptidase antibody Aminopeptidase M antibody Aminopeptidase N antibody AMPN_HUMAN antibody ANPEP antibody AP M antibody AP N antibody AP-M antibody AP-N antibody APN antibody CD 13 antibody CD13 antibody CD13 antigen antibody gp150 antibody hAPN antibody LAP 1 antibody LAP1 antibody Microsomal aminopeptidase antibody Myeloid plasma membrane glycoprotein CD13 antibody p150 antibody PEPN antibody
Abbreviation
AP-N, hAPN, AP-M, CD13, ANPEP, APN, CD13, PEPN
Swiss Prot
P15144 Human, P97449 Mouse, P15684 Rat
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human CD13 aa 273-448 / 967.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Rat kidney tissue lysate, Hela liver tissue lysate, HT-29, A549, rat kdiney tissue, human liver tissue, human prostate cancer tissue, human kidney tissue, mouse colon tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB:1:500;IF-Cell:1:100-1:400;IHC-P:1:50-1:600;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 110 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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