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CD1a Rabbit Polyclonal Antibody

CAT: 0992-ER1902-73Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-73Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.
CAS Number
9007-83-4
Product Name Alternative
CD 1a antibody CD1 antibody CD1a antibody CD1A Antigen antibody CD1A antigen, a polypeptide antibody CD1a molecule antibody CD1A_HUMAN antibody cluster of differentiation 1 A antibody cortical thymocyte antigen CD1A antibody differentiation antigen CD1 alpha 3 antibody epidermal dendritic cell marker CD1a antibody FCB 6 antibody FCB6 antibody HTA 1 antibody HTA1 antibody hTa1 thymocyte antigen antibody OTTHUMP00000018907 antibody R 4 antibody R4 antibody T 6 antibody T-cell surface antigen T6/Leu-6 antibody T-cell surface glycoprotein CD1a antibody T6 antibody
Abbreviation
hTa1 thymocyte antigen, CD1a, CD1A
Swiss Prot
P06126 Human
Cellular Locus
Cell membrane. Endosome membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human CD1a aa 1-152 / 327.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
Human skin tissue lysates, 293.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 37 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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