ITPR2 Rabbit Polyclonal Antibody

ITPR2 Rabbit Polyclonal Antibody

• Description: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
• Product Name Alternative: 4 antibody 5-trisphosphate receptor antibody Inositol 1 4 5 trisphosphate receptor type 2 antibody Inositol 1,4,5-trisphosphate receptor type 2 antibody Inositol 145 trisphosphate receptor type 2 antibody InsP3 R2 antibody InsP3R2 antibody IP3 R2 antibody IP3 receptor antibody IP3 receptor isoform 2 antibody IP3R 2 antibody IP3R2 antibody ITPR 2 antibody Itpr2 antibody ITPR2_HUMAN antibody Type 2 inositol 1 4 5 trisphosphate receptor antibody Type 2 inositol 1 antibody Type 2 inositol 145 trisphosphate receptor antibody Type 2 InsP3 receptor antibody
• Abbreviation: IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2
• CAS Number: 9007-83-4
• Swiss Prot: Q14571 Human, Q9Z329 Mouse, P29995 Rat
• Cellular Locus: Endoplasmic reticulum membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human ITPR2 aa 1100-1450.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: Dot Blot, IF-Cell, IHC-P, FC
• Positive Control: HepG2, HT-29, SiHa, rat kidney tissue, human colon tissue, human breast tissue, mouse liver tissue.
• Concentration: 1 mg/mL
• Dilution: Dot Blot: 1:2,000-1:5,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50 -1:200 ;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 308 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No