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ITPR2 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-65Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-65Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
CAS Number
9007-83-4
Product Name Alternative
4 antibody 5-trisphosphate receptor antibody Inositol 1 4 5 trisphosphate receptor type 2 antibody Inositol 1,4,5-trisphosphate receptor type 2 antibody Inositol 145 trisphosphate receptor type 2 antibody InsP3 R2 antibody InsP3R2 antibody IP3 R2 antibody IP3 receptor antibody IP3 receptor isoform 2 antibody IP3R 2 antibody IP3R2 antibody ITPR 2 antibody Itpr2 antibody ITPR2_HUMAN antibody Type 2 inositol 1 4 5 trisphosphate receptor antibody Type 2 inositol 1 antibody Type 2 inositol 145 trisphosphate receptor antibody Type 2 InsP3 receptor antibody
Abbreviation
IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2
Swiss Prot
Q14571 Human, Q9Z329 Mouse, P29995 Rat
Cellular Locus
Endoplasmic reticulum membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human ITPR2 aa 1100-1450.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
Dot Blot, IF-Cell, IHC-P, FC
Positive Control
HepG2, HT-29, SiHa, rat kidney tissue, human colon tissue, human breast tissue, mouse liver tissue.
Concentration
1 mg/mL
Dilution
Dot Blot: 1:2,000-1:5,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50 -1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 308 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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