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NrCAM Rabbit Polyclonal Antibody

CAT: 0992-ER1803-64Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-64Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
CAS Number
9007-83-4
Product Name Alternative
Bravo antibody hBravo antibody Neuronal cell adhesion molecule antibody Neuronal surface protein Bravo antibody Ng CAM related antibody Ng-CAM-related antibody NgCAM related cell adhesion molecule antibody NgCAM-related cell adhesion molecule antibody Nr CAM antibody Nr-CAM antibody Nrcam antibody NRCAM_HUMAN antibody
Abbreviation
Nr-CAM, hBravo, Ng-CAM-related, NRCAM, KIAA0343
Swiss Prot
Q92823 Human, Q810U4 Mouse, P97686 Rat
Cellular Locus
Cell membrane, Secreted.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human NRCAM aa 723-903 / 1,304.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
SH-SY5Y cell lysate, A549, SH-SY5Y, SKOV-3, rat brain tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50 -1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 144 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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