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SDHB Rabbit Polyclonal Antibody

CAT: 0992-ER1803-63Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-63Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations associate with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
CAS Number
9007-83-4
Product Name Alternative
CWS2 antibody DHSB_HUMAN antibody FLJ92337 antibody Ip antibody Iron sulfur subunit antibody Iron sulfur subunit of complex II antibody Iron-sulfur subunit of complex II antibody mitochondrial antibody PGL 4 antibody PGL4 antibody SDH 1 antibody SDH antibody SDH1 antibody SDH2 antibody SDH2, homolog of antibody SdhB antibody SDHIP antibody Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial antibody Succinate dehydrogenase [ubiquinone] iron sulfur subunit antibody Succinate dehydrogenase [ubiquinone] iron-sulfur subunit antibody succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial antibody Succinate Dehydrogenase 1 Iron Sulfur Subunit antibody Succinate Dehydrogenase 2, S. cerevisiae, homolog of antibody Succinate dehydrogenase complex iron sulfur subunit B antibody Succinate dehydrogenase complex subunit B iron sulfur antibody Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein antibody succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody Succinate dehydrogenase iron sulfur protein antibody
Abbreviation
Ip, SDHB, SDH, SDH1
Swiss Prot
P21912 Human, Q9CQA3 Mouse, P21913 Rat
Cellular Locus
Membrane, Mitochondrion, Mitochondrion inner membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human SDHB aa 100-280.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Wild-type Hela whole cell lysate, Rat liver tissue, human liver tissue, mouse liver tissue, 293T, HT-29, Hela, rat heart tissue, human liver tissue, human kidney tissue, human skin tissue, mouse colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 32 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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