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LOXL2 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-41Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-41Size:100 µL
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Description
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
CAS Number
9007-83-4
Product Name Alternative
LOR 2 antibody LOR2 antibody LOX L2 antibody LOXL 2 antibody LOXL2 antibody LOXL2_HUMAN antibody Lysyl oxidase homolog 2 antibody Lysyl oxidase like 2 antibody Lysyl oxidase like protein 2 antibody Lysyl oxidase related 2 antibody Lysyl oxidase related protein 2 antibody Lysyl oxidase related protein WS9 14 antibody Lysyl oxidase-like protein 2 antibody Lysyl oxidase-related protein 2 antibody Lysyl oxidase-related protein WS9-14 antibody WS9 14 antibody
Abbreviation
LOXL2
Swiss Prot
Q9Y4K0 Human, P58022 Mouse, B5DF27 Rat
Cellular Locus
Endoplasmic reticulum. Nucleus. Secreted.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human LOXL2 aa 300-480.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
A431, A549, SiHa, rat testis tissue, human placenta tissue, human uterus tissue, mouse testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IF-Cell: 1:100;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 87 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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