AMBP Rabbit Polyclonal Antibody

The AMBP (α-1-Microglobulin/bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated a-1-Microglobulin and Bikunin. α-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, α-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-α-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike α-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis.

9007-83-4

Alpha 1 microglobulin/bikunin precursor antibody Alpha-1 microglycoprotein antibody AMBP antibody AMBP_HUMAN antibody Bikunin antibody Complex-forming glycoprotein heterogeneous in charge antibody EDC1 antibody Growth inhibiting protein 19 antibody HI 30 antibody HI-30 antibody HI30 antibody IATIL antibody Inter alpha trypsin inhibitor light chain antibody ITI antibody ITI LC antibody ITI-LC antibody ITILC antibody Protein HC antibody Trypstatin antibody Uronic-acid-rich protein antibody UTI antibody

Protein HC, ITI-LC, AMBP, HCP, ITIL

P02760 Human, Q07456 Mouse, Q64240 Rat

Secreted, Cytoplasm, cytosol, Cell membrane, Nucleus membrane, Mitochondrion inner membrane.

Recombinant protein within Human AMBP aa 120-320.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P, FC

HepG2 cell lysate, A549 cell lysate, Mouse liver tissue lysate, Mouse brain tissue lysate, Rat liver tissue lysate, Rat brain tissue lysate, HepG2, human liver tissue.

1 mg/mL

WB: 1:2,000 ;IF-Cell: 1:500 ;IHC-P: 1:1,000 ;FC: 1:1,000

Protein A affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 39 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.