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KCNA5 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-23Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-23Size:100 µL
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Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
CAS Number
9007-83-4
Product Name Alternative
ATFB7 antibody cardiac potassium channel antibody HCK1 antibody HK2 antibody HPCN1 antibody insulinoma and islet potassium channel antibody KCNA5 antibody KCNA5_HUMAN antibody KV1.5 antibody PCN1 antibody potassium channel 1 antibody Potassium channel, insulinoma and islet cell antibody Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody Potassium voltage gated channel subfamily A member 5 antibody Potassium voltage-gated channel subfamily A member 5 antibody Voltage-gated potassium channel HK2 antibody voltage-gated potassium channel protein Kv1.5 antibody Voltage-gated potassium channel subunit Kv1.5 antibody
Abbreviation
KCNA5
Swiss Prot
P22460 Human, Q61762 Mouse, P19024 Rat
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within rat KCNA5 aa 249-298 / 602.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
PANC-1 cell lysate, human brain tissue lysate, mouse hippocampus tissue lysate, rat hippocampus tissue lysate, rat skeletal muscle tissue, rat heart tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:200-1:800
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 67 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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