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GPX4 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-15Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-15Size:100 µL
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Description
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins . Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide . Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species . The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis . The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures . May be required to protect cells from the toxicity of ingested lipid hydroperoxides . Required for normal sperm development and male fertility. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion.
CAS Number
9007-83-4
Product Name Alternative
Glutathione peroxidase 4 antibody GPX 4 antibody GPX-4 antibody GPX4 antibody GPX4_HUMAN antibody GSHPx-4 antibody MCSP antibody mitochondrial antibody PHGPx antibody Phospholipid hydroperoxidase antibody Phospholipid hydroperoxide glutathione peroxidase antibody Phospholipid hydroperoxide glutathione peroxidase mitochondrial antibody snGPx antibody snPHGPx antibody Sperm nucleus glutathione peroxidase antibody
Abbreviation
PHGPx, GPx-4, GSHPx-4, GPX4
Swiss Prot
P36969 Human, O70325 Mouse, P36970 Rat
Cellular Locus
Cytoplasm. Mitochondrion.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human GPX4 aa 1-197 / 197.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Rat testis tissue lysate, HepG2, LOVO, MCF-7, mouse testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50 -1:600 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 22 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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