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Orai1 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-11Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-11Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orai1 (ORAI calcium release-activated calcium modulator 1), also known as ORAT1, CRACM1 (calcium release-activated calcium modulator 1) or TMEM142A (transmembrane protein 142A), is a 301 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai1 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Specifically, Orai1 functions as a pore subunit of the store-operated calcium release-activated calcium channel (CRAC) and is essential for proper function of the CRAC channel. CRAC channels are responsible for mediating calcium influx in T-cells and play an important role in the immune response. Mutations in the gene encoding Orai1 can result in severe combined immunodeficiency (SCID).
CAS Number
9007-83-4
Product Name Alternative
Calcium release activated calcium channel protein 1 antibody Calcium release activated calcium modulator 1 antibody Calcium release-activated calcium channel protein 1 antibody CRACM 1 antibody CRACM1 antibody CRCM1 antibody CRCM1_HUMAN antibody FLJ14466 antibody Orai 1 antibody ORAI calcium release activated calcium modulator 1 antibody orai1 antibody ORAT1 antibody Protein orai 1 antibody Protein orai-1 antibody TMEM 142A antibody TMEM142A antibody Transmembrane protein 142A antibody
Abbreviation
ORAI1, CRACM1, TMEM142A
Swiss Prot
Q96D31 Human, Q8BWG9 Mouse
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within mouse Orai1 aa 181-230 / 304.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
PC-3M, LOVO, MCF-7, human skin tissue, human esophagus tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
33 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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