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Tyk2 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-05Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-05Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.
CAS Number
9007-83-4
Product Name Alternative
JTK 1 antibody JTK1 antibody Non receptor tyrosine protein kinase 2 antibody Non receptor tyrosine protein kinase TYK2 antibody Non-receptor tyrosine-protein kinase TYK2 antibody OTTHUMP00000232745 antibody OTTHUMP00000232746 antibody OTTHUMP00000232748 antibody Protein Tyrosine Kinase 2 antibody TYK 2 antibody Tyk2 antibody TYK2_HUMAN antibody Tyrosine kinase 2 antibody
Abbreviation
TYK2
Swiss Prot
P29597 Human,
Cellular Locus
Cytoskeleton. Nucleus. Cytosol. Plasma membrane.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human TYK2 aa 390-620.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Raji cell lysate, Jurkat cell lysate, A549 cell lysate, MCF-7, human liver carcinoma tissue, human colon tissue, rat kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 134 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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TA382969TYK2 Rabbit Polyclonal Antibody
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