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FBXL18 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-89Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-89Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.
CAS Number
9007-83-4
Product Name Alternative
F box and leucine rich repeat protein 18 antibody F box/LRR repeat protein 18 antibody FBL18 antibody FBXL 18 antibody FLJ10776 antibody FLJ11467 antibody FLJ26934 antibody FLJ38075 antibody FLJ41541 antibody
Abbreviation
FBXL18, FBL18
Swiss Prot
Q96ME1 Human
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human FBXL18 aa 756-805 / 805.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Rat liver tissue, human liver tissue, mouse liver tissue, A549.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 88 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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