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ATG12 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-82Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-82Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atg12 (autophagy-related protein 12), also known as APG12, APG12L, FBR93 or HAPG12, is a 140 amino acid protein that is ubiquitously expressed and belongs to the Atg12 family of proteins. Atg12 is a homolog of the yeast protein Apg12 that participates in autophagy. Autophagy is a membrane trafficking mechanism that delivers cytoplasmic cargo to the vacuole/lysosome for degradation and recycling. In yeast, autophagy requires a protein conjugation system consisting of Apg12 covalently bound at the carboxy terminal glycine to lysine 149 of Apg5. Similarly in humans, Atg12 is essential for autophagy and localizes to the cytoplasm where it is covalently bound to APG5, a conjugation reaction that requires APG7, Atg10 and ATP. The Atg12-APG5 conjugate functions as an important regulator of the autophagic process and is required for the change in membrane morphology and development of autophagosomes. Due to alternative splicing events, two Atg12 isoforms exist.
CAS Number
9007-83-4
Product Name Alternative
APG12-like antibody APG12L antibody ATG12 antibody ATG12 autophagy related 12 homolog (S. cerevisiae) antibody ATG12 autophagy related 12 homolog antibody ATG12_HUMAN antibody Autophagy 12 antibody Autophagy-related protein 12 antibody FBR93 antibody HAPG12 antibody Ubiquitin-like protein ATG12 antibody
Abbreviation
APG12-like, ATG12, APG12, APG12L
Swiss Prot
O94817 Human
Cellular Locus
Cytoplasm, Membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human Atg12 aa 1-120.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
A431 cell lysate, human kidney tissue lysate, 293T cell lysate, human liver cancer tissue, human colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 15 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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