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BubR1 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-76Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-76Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human cells contain two related protein kinases, BUB1 and BUBR1, that appear to have evolved from a single ancestral BUB1 gene. Both kinases are concentrated near the surface of the kinetochore where they monitor kinetochore-microtubule interactions. BUB1 and BUBR1 bind to kinetochores and are postulated to be components of the mitotic checkpoint, which monitors kinetochore activities to determine if chromosomes have achieved alignment at the spindle equator. BUBR1 is essential for normal mitotic progression as it prevents cells from prematurely entering anaphase. BUB3 is a conserved component of the mitotic spindle assembly complex and is also involved with the essential spindle checkpoint pathway that operates during early embryogenesis.
CAS Number
9007-83-4
Product Name Alternative
Beta homolg of S. cerevisiae BUB 1 antibody Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody BUB 1B antibody BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody Bub1A antibody BUB1B antibody BUB1B_HUMAN antibody BUB1beta antibody BUBR1 antibody Budding Uninhibited by Benzimidazoles 1 beta antibody Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody hBUBR1 antibody MAD3/BUB1 related protein kinase antibody MAD3/BUB1-related protein kinase antibody MAD3L antibody Mitotic checkpoint gene BUB1B antibody Mitotic checkpoint kinase MAD3L antibody Mitotic checkpoint serine/threonine protein kinase BUB1 beta antibody Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antibody MVA1 antibody OTTHUMP00000160319 antibody Protein SSK1 antibody SSK 1 antibody SSK1 antibody
Abbreviation
hBUBR1, BUB1B, BUBR1, MAD3L, SSK1
Swiss Prot
O60566 Human
Cellular Locus
Nucleus, Cytoplasm, Cytoskeleton.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human BubR1 aa 310-620.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SH-SY-5Y cell lysate, Hela, SH-SY-5Y, SiHa, human spleen tissue, HL-60.
Concentration
1 mg/mL
Dilution
WB: 1:5,000-1:10,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 120 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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