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Securin Rabbit Polyclonal Antibody

CAT: 0992-ER1802-75Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-75Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology.
CAS Number
9007-83-4
Product Name Alternative
AW555095 antibody C87862 antibody Cut2 antibody EAP 1 antibody EAP1 antibody ESP1 associated protein 1 antibody Esp1-associated protein antibody hPTTG antibody MGC126883 antibody MGC138276 antibody Pds1 antibody Pituitary tumor transforming 1 antibody Pituitary tumor transforming protein 1 antibody Pituitary tumor-transforming 1, isoform CRA_a antibody Pituitary tumor-transforming 1, isoform CRA_b antibody Pituitary tumor-transforming gene 1 antibody Pituitary tumor-transforming gene 1 protein antibody PTTG 1 antibody PTTG antibody PTTG1 antibody PTTG1 protein antibody PTTG1_HUMAN antibody Pttg3 antibody Securin antibody Tumor transforming 1 antibody Tumor transforming protein 1 antibody Tumor-transforming protein 1 antibody TUTR 1 antibody TUTR1 antibody
Abbreviation
Tumor-transforming protein 1, hPTTG, PTTG1, EAP1, PTTG, TUTR1
Swiss Prot
O95997 Human
Cellular Locus
Nucleus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human Securin aa 2-202.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HUVEC cell lysate, HUVEC, PC-3M, human tonsil tissue, mouse testis tissue, rat testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500;IHC-P: 1:200-1:500;IF-Cell: 1:200-1:500;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 22 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No