Dnmt3b Rabbit Polyclonal Antibody
CAT:
992-ER1802-55
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Dnmt3b Rabbit Polyclonal Antibody
- Description: DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. Immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome is a result of defects in lymphocyte maturation resulting from aberrant DNA methylation caused by mutations in the DNMT3B gene. Variants of the gene can also contribute to nicotine dependency.
- Alternative Name: Cytosine 5methyltransferase 3B antibody DNA antibody DNA (cytosine 5) methyltransferase 3 beta antibody DNA (cytosine 5)-methyltransferase 3B antibody DNA (cytosine-5)-methyltransferase 3B antibody DNA methyltransferase HsaIIIB antibody DNA MTase HsaIIIB antibody DNM3B_HUMAN antibody Dnmt3b antibody EC 2.1.1.37 antibody ICF antibody ICF1 antibody M.HsaIIIB antibody MGC124407 antibody RP23-89H14.3 antibody
- Abbreviation: Dnmt3b, DNA MTase HsaIIIB, M.HsaIIIB, DNMT3B
- Swiss Prot: Q9UBC3 Human, O88509 Mouse,
- Cellular Locus: Nucleus.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide within N-terminal mouse Dnmt3b.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: IF-Cell, IHC-P, FC
- Positive Control: HeLa, human testis tissue, mouse testis tissue, rat testis tissue, rat brain tissue, K562.
- Concentration: 1 mg/mL
- Dilution: IF-Cell: 1:50-1:200 ;IHC-P: 1:1,000 ;FC: 1:50-1:100
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 96 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No