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SATB1 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-24Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-24Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.
CAS Number
9007-83-4
Product Name Alternative
DNA binding protein SATB1 antibody DNA-binding protein SATB1 antibody SATB homeobox 1 antibody SATB1 antibody SATB1_HUMAN antibody Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA) antibody Special AT rich sequence binding protein 1 antibody Special AT-rich sequence-binding protein 1 antibody
Abbreviation
SATB1
Swiss Prot
Q01826 Human, Q60611 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within N-terminal human SATB1 aa.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Mouse thymus tissue lysate,SH-SY-5Y, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:100;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 86 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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