DOCK4 Rabbit Polyclonal Antibody

DOCK4 Rabbit Polyclonal Antibody

• Description: DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.
• Product Name Alternative: Dedicator of cytokinesis protein 4 antibody Dock4 antibody DOCK4_HUMAN antibody KIAA0716 antibody
• Abbreviation: DOCK4, KIAA0716
• CAS Number: 9007-83-4
• Swiss Prot: Q8N1I0 Human, P59764 Mouse, F1LZ81 Rat
• Cellular Locus: Cytosol. Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human DOCK4 aa 1,917-1,966 / 1,966.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: HepG2, HUVEC, PC-3M, rat skeletal muscle tissue, human fetal skeletal muscle tissue, human prostate tissue, mouse skeletal muscle tissue.
• Concentration: 1 mg/mL
• Dilution: IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;WB: 1:500
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 225 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No