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ADAM10 Rabbit Polyclonal Antibody

CAT: 0992-ER1706-97Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1706-97Size:100 µL
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Description
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.
CAS Number
9007-83-4
Product Name Alternative
A disintegrin and metalloprotease domain 10 antibody A disintegrin and metalloproteinase domain 10 antibody AD 10 antibody AD10 antibody AD18 antibody ADA10_HUMAN antibody ADAM 10 antibody ADAM metallopeptidase domain 10 antibody ADAM10 antibody CD 156c antibody CD156c antibody CD156c antigen antibody CDw156 antibody disintegrin and metalloproteinase domain containing protein 10 antibody Disintegrin and metalloproteinase domain-containing protein 10 antibody HsT 18717 antibody HsT18717 antibody Kuz antibody Kuzbanian antibody Kuzbanian protein homolog antibody Kuzbanian, Drosophila, homolog of antibody MADM antibody Mammalian disintegrin metalloprotease antibody Mammalian disintegrin-metalloprotease antibody RAK antibody
Abbreviation
ADAM 10, ADAM10, KUZ, MADM
Swiss Prot
O14672 Human
Cellular Locus
Golgi apparatus, Plasma membrane, Cell junction, Cell membrane, Cell projection, Cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human ADAM10 aa 60-338.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
SiHa, human prostate tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:5,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 84 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No