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BMAL1 Rabbit Polyclonal Antibody

CAT: 0992-ER1706-71Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1706-71Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or brain and muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the ARNTL gene, also known as BMAL1, MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC. ARNTL encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome.[4] The ARNTL protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that ARNTL is the only clock gene without which the circadian clock fails to function in humans. ARNTL has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in ARNTL have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. ARNTL, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.
CAS Number
9007-83-4
Product Name Alternative
ARNT like protein 1 brain and muscle antibody Arntl antibody Aryl hydrocarbon receptor nuclear translocator like antibody Aryl hydrocarbon receptor nuclear translocator like protein 1 antibody Aryl hydrocarbon receptor nuclear translocator-like protein 1 antibody Basic helix loop helix PAS orphan MOP3 antibody Basic helix loop helix PAS protein MOP3 antibody Basic-helix-loop-helix-PAS protein MOP3 antibody bHLH PAS protein JAP3 antibody bHLH-PAS protein JAP3 antibody bHLHe5 antibody BMAL 1 antibody BMAL1_HUMAN antibody BMAL1c antibody Brain and muscle ARNT like 1 antibody Brain and muscle ARNT-like 1 antibody CG8727 PA antibody Class E basic helix-loop-helix protein 5 antibody cycle antibody JAP 3 antibody JAP3 antibody Member of PAS protein 3 antibody Member of PAS superfamily 3 antibody MGC47515 antibody MOP 3 antibody MOP3 antibody PAS domain-containing protein 3 antibody PASD 3 antibody PASD3 antibody TIC antibody
Abbreviation
bHLHe5, ARNTL, BHLHE5, BMAL1, MOP3, PASD3
Swiss Prot
O00327 Human, Q9WTL8 Mouse, Q9EPW1 Rat
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within N-terminal human BMAL1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SYSH5Y cell lysates, A549, MCF-7, human liver cncer tissue, human prostate tissue, mouse brain tissue, mouse prostate tissue, rat brain tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-2,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 69 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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