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PRTN3 Rabbit Polyclonal Antibody

CAT: 0992-ER1706-25Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1706-25Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.
CAS Number
9007-83-4
Product Name Alternative
ACPA antibody AGP 7 antibody AGP7 antibody AGP7 serine proteinase antibody Azurophil Granule Protein 7 antibody C ANCA antibody C ANCA antigen antibody C-ANCA antigen antibody CANCA antibody EC 3.4.21.76 antibody Leukocyte proteinase 3 antibody MBN antibody MBT antibody MBT WEGENER AUTOANTIGEN antibody Myeloblastin antibody Neutrophil proteinase 4 antibody NP 4 antibody NP-4 antibody NP4 antibody P29 antibody PR 3 antibody PR-3 antibody PR3 antibody Proteinase 3 antibody Proteinase3 antibody PRTN 3 antibody Prtn3 antibody PRTN3_HUMAN antibody Serine proteinase neutrophil Wegener granulomatosis autoantigen antibody Serine proteinase, neutrophil antibody Wegener autoantigen antibody Wegener granulomatosis autoantigen antibody
Abbreviation
PR-3, PR3, NP-4, PRTN3, MBN
Swiss Prot
P24158 Human, Q61096 Mouse
Cellular Locus
Cytoplasmic granule, Secreted, Cell membrane, Membrane raft.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within Human PRTN3 aa 50-248 / 256.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
U937, mouse marrow lysate, 293T, A549, SH-SY5Y, human spleen tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 28 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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