TPC2-A1-P

TPC2-A1-P

• CAS Number: 2804595-86-4
• UNSPSC Description: TPC2-A1-P is a powerful and membrane permeable agonist of?two pore?channel?2?(TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions?of?PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3].
• Target Antigen: Sodium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/tpc2-a1-p.html
• Purity: 99.76
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: BrC1=CC(C2=CC(C(O)=O)=C(C)N2CC3CCCCC3)=C(OC(F)(F)F)C=C1
• Molecular Weight: 460.28
• References & Citations: [1]Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.|[2]Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41(8):582-594.|[3]Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287(24):5284-5293.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported