TPC2-A1-N

TPC2-A1-N

• CAS Number: 136186-07-7
• UNSPSC Description: TPC2-A1-N is a powerful and Ca2+-permeable agonist of?two pore?channel?2?(TPC2), which plays its role by mimicking the physiological actions?of?NAADP. TPC2-A1-P reproducibly?evokes significant Ca2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells[1][2].
• Target Antigen: Calcium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/tpc2-a1-n.html
• Purity: 99.86
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC=C(C(F)(F)F)C=C1)/C(C#N)=C(C2=CC(Cl)=CC(Cl)=C2)\O
• Molecular Weight: 401.17
• References & Citations: [1]Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife|[2]Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41(8):582-594.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported