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SDM-8

CAT: 0804-HY-167830-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-167830-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDM-8 is a difluoro-analog of UCB-J.SDM-8 shows high SV2A binding affinity with a Ki of 0.58 nM. SDM-8 can be used in the study of Alzheimer's disease[1].
CAS Number
2242777-37-1
UNSPSC
12352005
Target
Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sdm-8.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@H](C2=CC(F)=CC(F)=C2)CN1CC3=CC=NC=C3C
Molecular Formula
C17H16F2N2O
Molecular Weight
302.32
References & Citations
[1]Li S, et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1544-1554.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Sdm-8
CAS Number2242777-37-1
PubChem CID138106851
IUPAC Name(4R)-4-(3,5-difluorophenyl)-1-[(3-methyl-4-pyridinyl)methyl]pyrrolidin-2-one
Molecular FormulaC17H16F2N2O
Molecular Weight302.32
XLogP2.2
Topological Polar Surface Area33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity396
SMILES
CC1=C(C=CN=C1)CN2C[C@H](CC2=O)C3=CC(=CC(=C3)F)F
InChI
InChI=1S/C17H16F2N2O/c1-11-8-20-3-2-12(11)9-21-10-14(6-17(21)22)13-4-15(18)7-16(19)5-13/h2-5,7-8,14H,6,9-10H2,1H3/t14-/m0/s1
InChIKey
JLTZBYZOWVBLBQ-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Sdm-8
CAS: 2242777-37-1
CID: 138106851
Formula: C17H16F2N2O
MW: 302.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.32
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass302.12306946
Monoisotopic Mass302.12306946
Topological Polar Surface Area33.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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