GSK2807 (Trifluoroacetate)

GSK2807 (Trifluoroacetate)

• CAS Number: 2245255-66-5
• UNSPSC Description: GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM[1][2].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/GSK2807_Trifluoroacetate.html
• Purity: 99.36
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
• Smiles: NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC[C@H](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O
• Molecular Weight: 566.53
• References & Citations: [1]Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.|[2]Kaniskan HÜ, et al. Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev. 2018 Feb 14;118(3):989-1068.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported