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EG00229 (trifluoroacetate)

CAT: 0804-HY-10799-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10799-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2[1].
CAS Number
1210945-69-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EG00229.html
Purity
98.03
Solubility
DMSO : ≥ 41.4 mg/mL
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O.O=C(O)C(F)(F)F
Molecular Formula
C19H20F3N7O7S3
Molecular Weight
611.60
Precautions
H302, H315, H319
References & Citations
[1]Jarvis A, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53 (5) :2215-26.|[2]Grun D, et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35 (33) :4379-87.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
E1119-25mgEG00229
A16237-50EG00229 50mg
A16237-10EG00229 10mg
A16237-5EG00229 5mg
A16237-2EG00229 2mg
A16237-1EG00229 1mg
A16237-100EG00229 100mg
A16237-25EG00229 25mg
A16237-10mM-DEG00229 10mM * 1mL in DMSO
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