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WBS22 rabbit pAb

CAT: 0855-ES12327-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12327-01Size:50 µL
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Background
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011]
Description
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11. 23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011],
UniProt
O43709
Swiss Prot
O43709
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human WBS22 AA range: 144-194
Target
WBS22
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm . Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492) . Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604) . Localization is not affected by glucocorticoid treatment (PubMed:24488492) . .
Gene ID (Human)
114049

UniProtKB · O43709

18S rRNA (guanine-N(7))-methyltransferase

BUD23_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43709
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BUD23
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.1.-
Processing
—
Secondary accessions
A8K501, C9K060, Q96P12, Q9BQ58, Q9HBP9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorMethyltransferaseTransferase

Cellular component

CytoplasmNucleus

PTM

PhosphoproteinUbl conjugation

Biological process

Ribosome biogenesisrRNA processingTranscriptionTranscription regulation

Ligand

S-adenosyl-L-methionine

Disease

Williams-Beuren syndrome

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