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Bongkrekic acid

CAT: 0804-HY-136406-01Size: 100 µg (2.06 mM in 100 µL Tris)Dry Ice: NoHazardous: No
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CAT#:0804-HY-136406-01Size:100 µg (2.06 mM in 100 µL Tris)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans[1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport[2].
CAS Number
11076-19-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
ATP Synthase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bongkrekic-acid.html
Concentration
2.06 mM in 100 μL Tris
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
OC(CC(/C=C/[C@@H](C)C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(C)=C\C=C(C)\C(O)=O)=C/C(O)=O)=O
Molecular Formula
C28H38O7
Molecular Weight
486.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Mehruba Anwar, et al. Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin. J Med Toxicol. 2017 Jun;13 (2) :173-179.|[2]C Dahout-Gonzalez, et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) |[3]Shuso Takeda, et al. Bongkrekic Acid as a Warburg Effect Modulator in Long-term Estradiol-deprived MCF-7 Breast Cancer Cells. Anticancer Res
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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