Macitentan-d4

Macitentan-d4

• CAS Number: 1258428-05-5
• UNSPSC Description: Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].
• Target Antigen: Apoptosis; Endothelin Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;GPCR/G Protein;Others
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Cardiovascular Disease
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
• Molecular Weight: 592.30
• References & Citations: [1]Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18(1):228.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported