Macitentan-d4

• Description :

  Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) [1].

• Product Name Alternative :

  ACT-064992-d4

• UNSPSC :

  12352005

• Target :

  Apoptosis; Endothelin Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; GPCR/G Protein; Others

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cardiovascular Disease

• Purity :

  98.03

• Solubility :

  DMSO : ≥ 50mg/mL

• Smiles :

  O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

• Molecular Formula :

  C19H16D4Br2N6O4S

• Molecular Weight :

  592.30

• References & Citations :

  [1]Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18 (1) :228.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  ETA; ETB

• CAS Number :

  [1258428-05-5]