Macitentan-d4

• UNSPSC Description:

  Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

• Target Antigen:

  Apoptosis; Endothelin Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis;GPCR/G Protein;Others

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cardiovascular Disease

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

• Molecular Weight:

  592.30

• References & Citations:

  [1]Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18(1):228.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1258428-05-5