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Macitentan-d4

CAT: 0804-HY-14184S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14184S-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) [1].
CAS Number
[1258428-05-5]
Product Name Alternative
ACT-064992-d4
UNSPSC
12352005
Target
Apoptosis; Endothelin Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; GPCR/G Protein; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Purity
98.03
Solubility
DMSO : ≥ 50mg/mL
Smiles
O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Molecular Formula
C19H16D4Br2N6O4S
Molecular Weight
592.30
References & Citations
[1]Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18 (1) :228.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
ETA; ETB

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